Gene information
Official symbol IRS2
Official full name insulin receptor substrate 2
Gene type protein-coding gene
Chromosome13q34
Gene familyPleckstrin homology domain containing
Resources
Entrez Gene 8660
HGNC HGNC:6126
Ensembl ENSG00000185950
Vega OTTHUMG00000017338
UCSC uc001vqv.4
GO terms: 96 records
GO Description Category LogP Number of genes Detail
GO:0001678 cellular glucose homeostasis GO Biological Processes -13.5994972 27 More
GO:0002793 positive regulation of peptide secretion GO Biological Processes -7.26567394 18 More
GO:0005975 carbohydrate metabolic process GO Biological Processes -4.30473825 38 More
GO:0005979 regulation of glycogen biosynthetic process GO Biological Processes -6.48443546 10 More
GO:0006109 regulation of carbohydrate metabolic process GO Biological Processes -13.1742479 35 More
GO:0007167 enzyme-linked receptor protein signaling pathway GO Biological Processes -26.8285253 93 More
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway GO Biological Processes -16.7048742 60 More
GO:0007420 brain development GO Biological Processes -11.5572036 75 More
GO:0008286 insulin receptor signaling pathway GO Biological Processes -3.0699689 9 More
GO:0009725 response to hormone GO Biological Processes -49.1091700 138 More
GO:0009743 response to carbohydrate GO Biological Processes -20.6536066 44 More
GO:0009746 response to hexose GO Biological Processes -16.2230361 35 More
GO:0009749 response to glucose GO Biological Processes -15.7538948 34 More
GO:0009896 positive regulation of catabolic process GO Biological Processes -13.5088608 63 More
GO:0010563 negative regulation of phosphorus metabolic process GO Biological Processes -21.7837721 71 More
GO:0010565 regulation of cellular ketone metabolic process GO Biological Processes -15.3155739 32 More
GO:0010675 regulation of cellular carbohydrate metabolic process GO Biological Processes -9.60411715 27 More
GO:0010676 positive regulation of cellular carbohydrate metabolic process GO Biological Processes -6.37680507 13 More
GO:0010827 regulation of glucose transmembrane transport GO Biological Processes -18.4601079 28 More
GO:0010828 positive regulation of glucose transmembrane transport GO Biological Processes -9.82015489 15 More
GO:0010906 regulation of glucose metabolic process GO Biological Processes -10.3110629 25 More
GO:0010907 positive regulation of glucose metabolic process GO Biological Processes -8.00848642 13 More
GO:0010962 regulation of glucan biosynthetic process GO Biological Processes -6.48443546 10 More
GO:0019725 cellular homeostasis GO Biological Processes -21.1508273 85 More
GO:0019900 kinase binding GO Molecular Functions -6.03057706 62 More
GO:0019901 protein kinase binding GO Molecular Functions -6.66055444 59 More
GO:0019902 phosphatase binding GO Molecular Functions -2.86314983 18 More
GO:0019903 protein phosphatase binding GO Molecular Functions -3.28869574 16 More
GO:0019904 protein domain specific binding GO Molecular Functions -3.48133193 23 More
GO:0030335 positive regulation of cell migration GO Biological Processes -66.7331035 139 More
GO:0030879 mammary gland development GO Biological Processes -8.79064244 23 More
GO:0032024 positive regulation of insulin secretion GO Biological Processes -3.33317104 10 More
GO:0032368 regulation of lipid transport GO Biological Processes -34.5766289 54 More
GO:0032369 negative regulation of lipid transport GO Biological Processes -16.5715041 21 More
GO:0032868 response to insulin GO Biological Processes -11.6850377 35 More
GO:0032869 cellular response to insulin stimulus GO Biological Processes -9.16399556 26 More
GO:0032870 cellular response to hormone stimulus GO Biological Processes -24.7707938 79 More
GO:0032881 regulation of polysaccharide metabolic process GO Biological Processes -7.60302561 13 More
GO:0032885 regulation of polysaccharide biosynthetic process GO Biological Processes -7.40593429 12 More
GO:0032890 regulation of organic acid transport GO Biological Processes -14.1608908 23 More
GO:0033500 carbohydrate homeostasis GO Biological Processes -23.7918768 50 More
GO:0033673 negative regulation of kinase activity GO Biological Processes -12.5521161 39 More
GO:0034284 response to monosaccharide GO Biological Processes -18.9205843 39 More
GO:0034762 regulation of transmembrane transport GO Biological Processes -31.7284805 100 More
GO:0034763 negative regulation of transmembrane transport GO Biological Processes -22.14661 42 More
GO:0034764 positive regulation of transmembrane transport GO Biological Processes -18.2616571 46 More
GO:0040017 positive regulation of locomotion GO Biological Processes -69.9490345 147 More
GO:0042326 negative regulation of phosphorylation GO Biological Processes -20.6187298 64 More
GO:0042593 glucose homeostasis GO Biological Processes -23.8963802 50 More
GO:0043086 negative regulation of catalytic activity GO Biological Processes -41.1437610 130 More
GO:0043255 regulation of carbohydrate biosynthetic process GO Biological Processes -8.87798147 21 More
GO:0043434 response to peptide hormone GO Biological Processes -26.1739008 69 More
GO:0043467 regulation of generation of precursor metabolites and energy GO Biological Processes -10.8295915 27 More
GO:0043549 regulation of kinase activity GO Biological Processes -36.8507249 123 More
GO:0045913 positive regulation of carbohydrate metabolic process GO Biological Processes -10.1978214 20 More
GO:0045936 negative regulation of phosphate metabolic process GO Biological Processes -21.8424865 71 More
GO:0046320 regulation of fatty acid oxidation GO Biological Processes -3.51698265 7 More
GO:0046324 regulation of glucose import GO Biological Processes -14.8736114 22 More
GO:0046326 positive regulation of glucose import GO Biological Processes -7.69659659 12 More
GO:0046887 positive regulation of hormone secretion GO Biological Processes -9.61661717 24 More
GO:0048732 gland development GO Biological Processes -26.3979320 74 More
GO:0050708 regulation of protein secretion GO Biological Processes -30.3716714 63 More
GO:0050714 positive regulation of protein secretion GO Biological Processes -15.7339081 32 More
GO:0050996 positive regulation of lipid catabolic process GO Biological Processes -5.87603013 9 More
GO:0051046 regulation of secretion GO Biological Processes -54.0079540 130 More
GO:0051047 positive regulation of secretion GO Biological Processes -32.2282376 71 More
GO:0051051 negative regulation of transport GO Biological Processes -46.8709407 107 More
GO:0051222 positive regulation of protein transport GO Biological Processes -13.8994291 46 More
GO:0051223 regulation of protein transport GO Biological Processes -25.2801266 81 More
GO:0051272 positive regulation of cellular component movement GO Biological Processes -66.5150412 143 More
GO:0051348 negative regulation of transferase activity GO Biological Processes -13.2006110 43 More
GO:0055082 cellular chemical homeostasis GO Biological Processes -17.6289728 71 More
GO:0055088 lipid homeostasis GO Biological Processes -20.8046481 43 More
GO:0060322 head development GO Biological Processes -11.995356 79 More
GO:0062012 regulation of small molecule metabolic process GO Biological Processes -26.8746473 69 More
GO:0062013 positive regulation of small molecule metabolic process GO Biological Processes -17.9792910 37 More
GO:0070201 regulation of establishment of protein localization GO Biological Processes -24.4831554 82 More
GO:0070873 regulation of glycogen metabolic process GO Biological Processes -6.66615417 11 More
GO:0071322 cellular response to carbohydrate stimulus GO Biological Processes -12.8816523 25 More
GO:0071326 cellular response to monosaccharide stimulus GO Biological Processes -13.2453179 24 More
GO:0071331 cellular response to hexose stimulus GO Biological Processes -12.5306046 23 More
GO:0071333 cellular response to glucose stimulus GO Biological Processes -12.7795214 23 More
GO:0071375 cellular response to peptide hormone stimulus GO Biological Processes -15.9961580 44 More
GO:0071417 cellular response to organonitrogen compound GO Biological Processes -26.3253267 90 More
GO:0090277 positive regulation of peptide hormone secretion GO Biological Processes -6.66447400 17 More
GO:1901652 response to peptide GO Biological Processes -34.9047734 89 More
GO:1901653 cellular response to peptide GO Biological Processes -21.5212108 58 More
GO:1901699 cellular response to nitrogen compound GO Biological Processes -26.9091664 96 More
GO:1903530 regulation of secretion by cell GO Biological Processes -45.6472055 114 More
GO:1903532 positive regulation of secretion by cell GO Biological Processes -27.9542102 63 More
GO:1903829 positive regulation of protein localization GO Biological Processes -12.9651258 57 More
GO:1904951 positive regulation of establishment of protein localization GO Biological Processes -13.0308630 46 More
GO:1905952 regulation of lipid localization GO Biological Processes -40.6150331 64 More
GO:1905953 negative regulation of lipid localization GO Biological Processes -25.1573575 31 More
GO:2000106 regulation of leukocyte apoptotic process GO Biological Processes -11.3593886 22 More
GO:2000147 positive regulation of cell motility GO Biological Processes -67.8620360 143 More
KEGG pathways: 7 records
KEGG Description Category LogP Number of genes Detail
hsa04068 FoxO signaling pathway KEGG Pathway -6.87449445 21 More
hsa04140 Autophagy - animal KEGG Pathway -3.52554737 16 More
hsa04910 Insulin signaling pathway KEGG Pathway -1.75646958 6 More
hsa04920 Adipocytokine signaling pathway KEGG Pathway -10.4150431 19 More
hsa04930 Type II diabetes mellitus KEGG Pathway -3.96920305 9 More
hsa04931 Insulin resistance KEGG Pathway -8.40376708 21 More
hsa04935 Growth hormone synthesis, secretion and action KEGG Pathway -2.82078524 13 More
Drug-Gene interaction
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Related drugs: 3 records
Related study: 1 record
Molecular factor Omics type Application Objective MI type Reference
Chr13:110116187 hypomethylation epigenomics ischemic cardiac events[prognosis (bad)] myocardial infarction Thunders M et al. Epigenetics. 2019
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